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Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

Virtual learning object about oral ulcerative lesions: controlled educational intervention study
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ZIEGER, Renata de Almeida

; HUGO, Fernando Neves

; THIEME, Stéfanie

; JARDIM, Luisa Comerlato

; KUPSTAITIS, Lorenzo Costa

; FRICHEMBRUDER, Karla

; WAGNER, Vivian Petersen

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; MARTINS, Marco Antonio Trevizani

Brazilian Oral Research

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2023, Volume 37 elocation e118

Resumo: En | Texto: En | PDF: En

Abstract The aim of this study was to develop a virtual learning object (VLO) to teach undergraduate dental students about the diagnostic and therapeutic approaches to oral ulcerative lesions. The VLO was developed with information on the diagnostic process, lesion classification, and clinical-surgical management of oral ulcerative lesions. The VLO content was initially validated by a group of specialists. Learning was evaluated in a sample of 58 undergraduate dental students, divided into control group (conventional theoretical class, n = 29) and intervention group (interaction with VLO, n = 29). All students answered a pre-test and post-test questionnaire. The VLO group also answered a specific questionnaire on the evaluation of the VLO. Both quantitative and qualitative descriptive analyses were performed. The validation showed that professors and students considered the VLO adequate. The use of the VLO was recommended by 100% of professors and 86.6% of students. In the intervention group, the results showed a significantly higher number of correct answers in the post-test (p < 0.01). In conclusion, the VLO proved to be a useful tool for teaching oral medicine, contributing significantly to the knowledge of ulcerated lesions in the mouth.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0118

Prognostic factors from squamous cell carcinoma of the hard palate, gingiva and upper alveolar ridge
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Kovalski, Luan Nathiel Santana

; Zanella, Virgilio Gonzalez

; Jardim, Luisa Comerlato

; Só, Bruna Barcelos

; Girardi, Fabio Muradás

; Kroef, Ricardo Gallicchio

; Barra, Marinez Bizarro

; Carrard, Vinicius Coelho

; Martins, Manoela Domingues

; Martins, Marco Antonio Trevizani

Brazilian Oral Research

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2022, Volume 36 elocation e058

Resumo: En | Texto: En | PDF: En

Abstract: The purpose of this study was to evaluate the clinicodemographic characteristics and treatment protocol as prognostic factors in patients with oral squamous cell carcinoma (OSCC) of the hard palate, upper gingiva, and alveolar ridge (HPUGAR). This retrospective cohort study collected data of patients treated in two head and neck surgery departments in southern Brazil between 1999 and 2021. Information on clinicodemographic data, habits, site, size, clinical aspect, clinical staging, cervical metastasis, treatment, and survival was collected. Associations between independent variables and outcomes were assessed using Pearson's chi-square test and binary regression. Kaplan–Meier test was employed to compare the survival between the neck approaches. Forty-one patients were included; most were male (61%), with a mean age of 68.8 (± 13.9) years. The consumption of tobacco (p = 0.003) and alcohol (p = 0.02) was significantly higher in male than in female patients. The main clinical features observed in the study sample were lesions larger than 2 cm (48.7%), no cervical (90.2%), or distant metastasis (90.2%). Surgery alone was the main treatment approach (48.8%). The watch-and-wait strategy was adopted in 34 cases (83.0%), while elective neck dissection was applied in five (12.2%). Only two patients with cN0 disease (4.9%) presented with cervical metastasis at follow-up. Eight patients (12.2%) died of the disease. Clinicodemographic variables, habits, surgical margins, and histological subtype were not significantly associated with cervical metastasis or survival. Cervical metastasis (p = 0.004) was associated with poor survival. No difference was detected in survival between different neck approaches (p = 0.28). Cervical metastasis and local recurrence are negative prognostic factors for HPUGAR OSCC.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0058

Distance learning course improves primary care dentists’ diagnosis and self-efficacy in the management of oral lesions
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CARDOSO, Fernanda Brochier

; WAGNER, Vivian Petersen

; CORRÊA, Ana Paula Borngräber

; MARTINS, Marco Antônio Trevizani

; MARTINS, Manoela Domingues

; D’ÁVILA, Otávio Pereira

; GONÇALVES, Marcelo Rodrigues

; HARZHEIM, Erno

; UMPIERRE, Roberto Nunes

; CARRARD, Vinicius Coelho

Brazilian Oral Research

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2022, Volume 36 elocation e101

Resumo: En | Texto: En | PDF: En

Abstract Oral cancer represents a public health issue because of its high mortality rate, resulting mainly from diagnostic delays. Insufficient training in oral diagnosis is usually perceived by dentists. Distance learning could be used as an auxiliary tool to bridge that gap. This study evaluated the impact of a distance learning course on oral mucosal lesion diagnosis offered to public healthcare dentists. Participants of an online course answered a pretest/posttest comprising clinical images of 30 clinical cases. Participants were questioned about the diagnosis and informed their decision on the cases (referring the cases to a specialist or managing them themselves), as a parameter of perceived self-efficacy. A total of 442 dentists enrolled in the course. Their pass rate was 97%. Classification of the nature of the lesions, diagnostic hypotheses, sensitivity, and specificity improved by 13.4%, 10.0%, 13.4%, and 6.6%, respectively (p<0.01, Wilcoxon test). Regarding management, there was a 16.6% reduction in the intention to refer cases, while confidence in the diagnosis of benign lesions increased by 40%. A distance learning course may be useful in continuing education actions for primary care dentists, improving their diagnostic abilities and encouraging them in the management of oral lesions. Moreover, this strategy could contribute to disseminating knowledge to remote regions, particularly among primary health care professionals.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0101

Analysis of referrals to the stomatology service in a Southern Brazilian hospital: a retrospective study
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ZIGMUNDO, Gisele Corrêa de Oliveira

; SCHMIDT, Tuany Rafaeli

; SILVEIRA, Felipe Martins

; NEVES, Matheus

; MARTINS, Marco Antônio Trevizani

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

Brazilian Oral Research

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2021, Volume 35 elocation e072

Resumo: En | Texto: En | PDF: En

Abstract This paper intends to describe the demand for referrals to the stomatology service requested by the medical teams for inpatients in a reference hospital in the south of Brazil. This research is a retrospective cross-sectional descriptive study focusing on data collection and assessment of information about referrals to the stomatology unit carried out from January 2008 to December 2018. All information was obtained from the hospital management software database, then transferred and analyzed individually for descriptive statistics. A total of 4433 cases were referred to the stomatology team, with an average of 403 cases by year. Hematology/hemato-oncology (37.3%) was the specialty asking for the majority of the referrals, followed by Oncology (20.4%) and Pneumology (8.2%). The mean patients’ profile was males (55.5%), receiving a diagnosis of oral mucositis (43.5%), and with the first and second decades of life being the most prevalent ones (34.9%), with a mean age of 34.8±22.3 years. The most common treatment performed by the stomatology team was the photobiomodulation therapy (44.8%). This retrospective study demonstrated the important profile of the stomatological care in hospitalized patients from a specific hospital, especially referred by the hematology/hemato-oncology team. These results evidenced the importance of the stomatology specialty in the hospital environment.

https://doi.org/10.1590/1807-3107bor-2021.vol35.0072 124 downloads

Synchronous teleconsultation in the management of temporomandibular disorder
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Stüermer, Vanessa Müller

; Roxo-Gonçalves, Michelle

; Carrard, Vinicius Coelho

; Gonçalves, Marcelo Rodrigues

; Goulart, Bárbara Niegia Garcia de

Revista CEFAC

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2021, Volume 23 Nº 4 elocation e5321

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: to analyze synchronous teleconsultation as a support tool in the management of temporomandibular disorders in primary health care and to identify which factors have an impact on decisions about teleconsultation. Methods: retrospective study perfomed in TelessaúdeRS, between May 2018 to May 2020. This study used primary data from synchronous teleconsultation, requested by primary health care professionals and carried out by multiprofessional teleconsultants. The data collected were the information reported by the requester, the teleconsultant's suggestions and if there was referral of the patient for specialized care after teleconsultation. The statistical association was investigated between patient characteristics and decision of teleconsultation; and teleconsultation conduct suggestions and decision of teleconsultation, using Fisher's exact test and modeling was performed using binary logistic regression considering 5% of significance (p≤0.05). Results: during the period, 56 teleconsultations had a temporomandibular diagnostic hypothesis, these 79.2% patients were female and the average age was 43.7 years. In 59.1% of teleconsultations, primary care management was suggested, with 72.4% of patients being managed. An association was found between the decision of teleconsultation and referral to specialized care (p <000.1). The trauma report (p = 0.004) was associated with a greater chance of being referred for special care and suggestions for pharmacological (p <0.001) and non-pharmacological (p = 0.007) treatments were introduced among the teleconsultation managed in primary care. Conclusion: teleconsultation helped to manage the majority of temporomandibular disorder, streamlining care and having the potential to avoid unnecessary referrals to special care.

https://doi.org/10.1590/1982-0216/20212345321

BMI-1 expression increases in oral leukoplakias and correlates with cell proliferation
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KLEIN, Isadora Peres

; MEURER, Luise

; DANILEVICZ, Chris Krebs

; SQUARIZE, Cristiane Helena

; MARTINS, Manoela Domingues

; CARRARD, Vinicius Coelho

Journal of Applied Oral Science

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2020, Volume 28 elocation e20190532

Resumo: En | Texto: En | PDF: En

Abstract Oral leukoplakia (OL) is a white lesion of an indeterminate risk not related to any excluded (other) known diseases or disorders that carry no increased risk for cancer. Many biological markers have been used in an attempt to predict malignant transformation; however, no reliable markers have been established so far. Objective To evaluate cell proliferation and immortalization in OL, comparing non-dysplastic (Non-dys OL) and dysplastic OL (Dys OL). Methodology This is a cross-sectional observational study. Paraffin-embedded tissue blocks of 28 specimens of Non-dys OL, 33 of Dys OL, 9 of normal oral mucosa (NOM), 17 of inflammatory hyperplasia (IH), and 19 of oral squamous cell carcinomas (OSCC) were stained for Ki-67 and BMI-1 using immunohistochemistry. Results A gradual increase in BMI-1 and K-i67 expression was found in oral carcinogenesis. The immunolabeling for those markers was higher in OSCC when compared with the other groups (Kruskal-Wallis, p<0.05). Ki-67 expression percentage was higher in OL and in IH when compared with NOM (Kruskal-Wallis/Dunn, p<0.05). Increased expression of BMI-1 was also observed in OL when compared with NOM (Kruskal-Wallis/Dunn, p<0.05). No differences were observed in expression of both markers when non-dysplastic and dysplastic leukoplakias were compared. A significant positive correlation between Ki-67 and BMI-1 was found (Spearman correlation coefficient, R=0.26, p=0.01). High-grade epithelial dysplasia was associated with malignant transformation (Chi-squared, p=0.03). Conclusions These findings indicate that BMI-1 expression increases in early oral carcinogenesis and is possibly associated with the occurrence of dysplastic changes. Furthermore, our findings indicate that both Ki-67 and BMI-1 are directly correlated and play a role in initiation and progression of OSCC.

https://doi.org/10.1590/1678-7757-2019-0532 1012 downloads

Comparative effectiveness of photobiomodulation and manual therapy alone or combined in TMD patients: a randomized clinical trial
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BROCHADO, Fernanda Thomé

; JESUS, Luciano Henrique de

; CARRARD, Vinicius Coelho

; FREDDO, Angelo Luiz

; CHAVES, Karen Dantur

; MARTINS, Manoela Domingues

Brazilian Oral Research

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2018, Volume 32 elocation e50

Resumo: En | Texto: En | PDF: En

Abstract The effectiveness of photobiomodulation (PBM) and manual therapy (MT), alone or combined (CT), were evaluated in pain intensity, mandibular movements, psychosocial aspects, and anxiety symptoms of temporomandibular disorder (TMD) patients. Fifty-one TMD patients were randomly assigned to three groups: the PBM group (n = 18), which received PBM with 808 nm, 100 mW, 13.3 J/cm2, and 4 J per point; the MT group (n=16) for 21 minutes each session on masticatory muscles and temporomandibular joint TMJ; and the CT group (n = 17), applied during twelve sessions. Seven evaluations were performed in different moments using visual analogue scale (VAS), Research Diagnosis Criteria for Temporomandibular Disorders (RDC/TMD) Axis I and II, and Beck anxiety inventory (BAI). All groups demonstrated reductions in pain and improvement in jaw movements during treatment and at follow-up (< 0.001). The assessment of psychosocial aspects of TMD, comparing baseline and follow-up in all treatment groups, revealed that treatment did not promote modification in the intensity of chronic pain (p > 0.05). However, depression symptoms showed a reduction in PBM and CT groups (p≤0.05). All treatments promoted reduction in physical symptoms with and without pain and enhancement of jaw disabilities (p ≤ 0.05). MT promotes improvement in 5 functions, PBM in 2, and CT in 1 (p < 0.001). BAI analysis revealed that all treatments lead to a reduction in anxiety symptoms (p≤0.05). All protocols tested were able to promote pain relief, improve mandibular function, and reduce the negative psychosocial aspects and levels of anxiety in TMD patients. However, the combination of PBM and MT did not promote an increase in the effectiveness of both therapies alone.

https://doi.org/10.1590/1807-3107bor-2018.vol32.0050 7089 downloads

Agreement between clinical and histopathologic diagnoses and completeness of oral biopsy forms
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MENDEZ, Marina

; HAAS, Alex Nogueira

; RADOS, Pantelis Varvaki

; SANT’ANA FILHO, Manoel

; CARRARD, Vinicius Coelho

Brazilian Oral Research

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2016, Volume 30 Nº 1 elocation e94

Resumo: En | Texto: En | PDF: En

Abstract The present study aimed to assess the rate of agreement between clinical and histopathological diagnoses and to report the frequency of completed forms for specimens that were subjected to histopathological examination and retrospectively examined. Data from 8,168 specimens submitted to histopathological examination were retrieved from the records. A total of 5,368 cases were included. Agreement was defined based on the definition of lesion nature according to its diagnostic category. Sensitivity, specificity, and positive and negative predictive values were calculated for each diagnostic category. The highest rate of agreement was observed for periapical lesions (92.6%), followed by potentially malignant disorders (90.1%) and non-neoplastic proliferative disorders (89.3%). Low rates of histopathological confirmation of the clinical impression were observed for mesenchymal tumors (25.0%) and cysts (44.2%). Sensitivity values were > 0.70 for all lesions, except for cysts (0.51). Specificity was relatively high, ranging from 0.97 to 1.00. The frequency of incomplete biopsy forms ranged from 16.8% (malignant tumors of oral mucosal epithelium) to 51.0% (nonspecific inflammatory reaction). The most frequently completed biopsy forms corresponded to epithelial malignant tumors (83.2%) and glandular inflammation (72.3%). In conclusion, there was an acceptable level of agreement. The low level of completeness of biopsy forms indicates little awareness about the relevance of gathering detailed information during clinical examination.

https://doi.org/10.1590/1807-3107BOR-2016.vol30.0094 1821 downloads

10.

Oral mucosal lesions and their association with sociodemographic, behavioral, and health status factors
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GHENO, José Nicolau

; MARTINS, Marco Antonio Trevizani

; MUNERATO, Maria Cristina

; HUGO, Fernando Neves

; SANT’ANA FILHO, Manoel

; WEISSHEIMER, Camila

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

Brazilian Oral Research

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2015, Volume 29 Nº 1 elocation 00289

Resumo: En | Texto: En | PDF: En

The aim of this study was to evaluate the frequency of oral mucosal lesions and their associations with sociodemographic, health, and behavioral factors in a southern Brazilian population. Information was collected from participants (n = 801) using a structured questionnaire during an oral cancer screening campaign held at an agribusiness show in southern Brazil in 2009. Data were described using frequency distributions or means and standard deviations. Associations between independent variables and outcomes were assessed using the Chi-squared test. A total of 465 lesions were detected (actinic cheilitis: n = 204, 25.5%; candidiasis: n = 50, 6.2%; fibrous inflammatory hyperplasia: n = 42, 5.2%; ulceration, n = 33, 4.1%; hemangioma: n = 14, 1.7%; leukoplakia: n = 11, 1.4%). Candidiasis, actinic cheilitis, and fibrous inflammatory hyperplasia were associated significantly with literacy. Actinic cheilitis was also associated significantly with sun exposure and hat use, and leukoplakia was associated with smoking. The high frequency of oral mucosal lesions observed highlights the importance of education about risk factors. Additionally, training of health professionals, mainly those from public health services, in the use of preventive and community education strategies is needed.

https://doi.org/10.1590/1807-3107BOR-2015.vol29.0093 4145 downloads

11.

A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay
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OLIVEIRA, Maria Laura Cosetti

; WAGNER, Vivian Petersen

; SANT'ANA FILHO, Manoel

; CARRARD, Vinicius Coelho

; HUGO, Fernando Neves

; MARTINS, Manoela Domingues

Brazilian Oral Research

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2015, Volume 29 Nº 1 Páginas 1 - 8

Resumo: En | Texto: En | PDF: En

The aim of this study was to evaluate the demographic, clinical, and therapeutic characteristics and predictive factors of poor prognosis in patients with primary oral squamous cell carcinoma (OSCC) in Uruguay. Medical records of patients with the diagnosis of primary OSCC treated between 2000 and 2010 in Uruguayan public hospitals were selected. Data on demographic characteristics, risk factors, clinical features, treatment, and outcome were collected. Associations of independent variables with outcomes were assessed using Pearson chi-squared and Fisher's tests. Of 200 patients with OSCC, 79.4% were men (3.8:1 male:female ratio), with a mean age of 60.75 ± 11.26 years. Tobacco and alcohol consumption were reported by 85.3% and 63.5% of patients, respectively. The most commonly affected location was the tongue (42.5%), with lesions exhibiting ulcerous aspects in 87.9% of cases and pain at the time of diagnosis in 70.4% of cases. One hundred sixty-one (82.1%) patients had advanced-stage (III/IV) OSCC. Surgery was the most common treatment option, and the overall 5-year survival rate was 58.5%. Univariate analysis showed that the predictors of poor prognosis were clinical aspect, size, regional metastasis, clinical stage, and treatment. In Uruguay, OSCC is diagnosed late, which is associated with a low survival rate. Educational and preventive measures and investment to improve early diagnosis should be undertaken.

https://doi.org/10.1590/1807-3107BOR-2015.vol29.0075 3181 downloads

12.

Atrasos nos encaminhamentos de pacientes com câncer bucal: avaliação qualitativa da percepção dos cirurgiões-dentistas
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Lombardo, Eduardo Madruga

; Cunha, Amanda Ramos da

; Carrard, Vinicius Coelho

; Bavaresco, Caren Serra

Ciência & Saúde Coletiva

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Abr 2014, Volume 19 Nº 4 Páginas 1223 - 1232

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

O objetivo deste estudo é verificar, na percepção dos cirurgiões-dentistas atuantes em Atenção Primária em Saúde (APS) em Porto Alegre (RS), quais as possíveis razões que justifiquem o atraso da chegada do paciente com câncer bucal aos setores de atenção em saúde de maior complexidade. O presente estudo teve como público-alvo cirurgiões-dentistas atuantes em cinco diferentes realidades laborais em APS em Porto Alegre. Foram utilizados como critérios de inclusão profissionais com formação em APS e que estivessem atuando na Atenção Básica. O instrumento para coleta de dados foi a técnica de grupo focal com aplicação de questionário estruturado. Uma vez coletados os dados, foi realizada análise interpretativa e categorização das informações em quatro eixos centrais: profissional, equipe, comunidade e rede de serviços. Os resultados sugerem que os seguintes fatores estão associados ao atraso da chegada do paciente com câncer bucal aos setores de atenção em saúde de maior complexidade: falha na identificação precoce, ausência de trabalho multidisciplinar, desvalorização da necessidade de corresponsabilização pela própria saúde por parte da comunidade e a deficiência da rede de atenção no que tange a qualidade da comunicação entre profissionais de diferentes níveis de atenção.

The scope of this study was to verify the possible reasons to justify the delay in the referral of oral cancer patients to specialized health care sectors from the standpoint of the dental surgeons involved in Primary Health Care (PHC) in Porto Alegre, state of Rio Grande do Sul. This target public of this study was dental surgeons working in five different labor environments in PHC in Porto Alegre. Criteria for inclusion was dental surgeons graduated in and working in PHC. The data collection instrument was the focus group technique and application of a structured questionnaire. After data collection, interpretative analysis was conducted with classification of the information under four main headings: professional, team, community and services network. The results suggest that there are several factors associated with delayed in referral of patients with oral cancer to specialized health care sectors. These include omission of early diagnosis, lack of multidisciplinary work and insufficient attention to the need for joint community responsibility with patients for their own health status. It is also due to deficiencies in the health service network, specifically regarding the quality of communication between professionals at different levels of the health services.

https://doi.org/10.1590/1413-81232014194.00942013 4075 downloads

13.

Atrasos nos encaminhamentos de pacientes com câncer bucal: avaliação qualitativa da percepção dos cirurgiões-dentistas
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Lombardo, Eduardo Madruga

; Cunha, Amanda Ramos da

; Carrard, Vinicius Coelho

; Bavaresco, Caren Serra

Ciência & Saúde Coletiva

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Abr 2014, Volume 19 Nº 4 Páginas 1223 - 1232

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232014194.00942013 1352 downloads

14.

A 10-year study of specimens submitted to oral pathology laboratory analysis: lesion occurrence and demographic features
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Mendez, Marina

; Carrard, Vinicius Coelho

; Haas, Alex Nogueira

; Lauxen, Isabel da Silva

; Barbachan, João Jorge Diniz

; Rados, Pantelis Varvaki

; Sant'Ana Filho, Manoel

Brazilian Oral Research

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Jun 2012, Volume 26 Nº 3 Páginas 235 - 241

Resumo: En | Texto: En | PDF: En

The purpose of the present paper was to describe the range of lesions histologically diagnosed in an oral pathology laboratory in southern Brazil. A retrospective study of 8,168 specimen analyses recorded between 1995 and 2004 was conducted. The records were retrieved from the Oral Pathology Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, RS, Brazil. A total of 6,831 valid cases (83.63%) were examined. Of these, inflammatory lesions were the most common occurrences (n = 4,320; 63.24%). Benign and malignant tumors accounted for 7.66% (n = 523) and 1.9% (n = 130) of the occurrences, respectively. Significant associations were observed between nonneoplastic proliferative disorders and benign mesenchymal tumors in females, and between squamous cell carcinoma and leukoplakia in males. Most diagnoses were benign in nature and had an inflammatory etiology. The association of some demographic characteristics with the occurrence of lesions suggests that these characteristics should be considered in performing differential diagnoses.

4982 downloads Citado 3 vezes em SciELO

15.

Biocompatibility of RealSeal, its primer and AH Plus implanted in subcutaneous connective tissue of rats
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Grecca, Fabiana Soares

; Kopper, Patrícia Maria Poli

; Santos, Régis Burmeister dos

; Fossati, Anna Christina

; Carrard, Vinicius Coelho

; Acasigua, Gerson Arison Xavier

; Figueiredo, José Antônio Poli de

Journal of Applied Oral Science

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Fev 2011, Volume 19 Nº 1 Páginas 52 - 56

Resumo: En | Texto: En | PDF: En

OBJECTIVE: This study tested rat connective tissue response to RealSeal, RealSeal primer or AH Plus after 7, 15, 30, 60 and 90 days of implantation. MATERIAL AND METHODS: Thirty Wistar rats had subcutaneous sockets created on their back and received four implants each of polyethylene tubes containing one of the materials tested according to the groups: AH (AH Plus Sealer); RS (RealSeal Sealer); RP (RealSeal Primer); CG (control group - empty tube). After histological processing, sections were analyzed to identify the presence of neutrophils, lymphocytes and plasma cells, eosinophils, macrophages and giant cells, as well as fibrous capsule and abscesses, by an examiner using light microscope. Kruskal-Wallis and multiple-comparisons test were used for statistical analysis. Significance level was set at 5%. RESULTS: Lymphoplasmacytic infiltrate scores significantly higher than those of the control group were observed at 14 and 60 days in AH group, and at 90 days in RS group (p<0.05). There were no differences in terms of presence of macrophages, giant cells, eosinophils, neutrophils or fibrosis. AH Plus group scored higher for abscesses at 7 days than after any other period (p=0.031). RP group scored higher for lymphoplasmacytic infiltrate at 14 days than at 90 days (p=0.04). CONCLUSION: The main contribution of this study was to demonstrate that issues involved with tissue tolerance of a Resilon-containing sealer, RealSeal Sealer, cannot be attributed to its primer content.

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